Recent advances in direct 1,2-hydroxydifluoromethylation of olefins

Document Type : Review Article

Authors

1 Institute of Biochemistry, Department of Biotechnology, Samarkand State University, Samarkand, Uzbekistan.

2 Urgench State Pedagogical Institute, Urgench, Uzbekistan.

3 Department of Basic Medical Sciences, Kimyo International University in Tashkent, Samarkand, Uzbekistan.

4 Department of Epidemiology, Infectious Diseases and Nursing, Fergana Medical Institute of Public Health, Fergana, Uzbekistan.

5 Department of Light Industry Technologies and Equipment, Faculty of Chemical Technologies, Urgench State University named after Abu Raykhan Beruni, Urgench, Uzbekistan.

6 Department of the History of Uzbekistan, Karshi State University, Karshi, Uzbekistan.

7 Department of Microbiology, Bukhara State Medical Institute, Bukhara, Uzbekistan.

8 Department of Chemistry, Andijan State University, Andijan, Uzbekistan.

9 Tashkent Institute of Chemical Technology, Tashkent, Uzbekistan.

10 Bukhara State University, Bukhara, Uzbekistan.

Abstract
Due to its important role in drug discovery and its ability to significantly modify the physicochemical and biological properties of bioactive compounds, considerable research efforts have recently focused on the development of efficient and selective methods to incorporate the difluoromethyl group into organic molecules. In this context, the direct vicinal hydroxylative difluoromethylation of olefinic double bonds has emerged as an efficient one-step strategy for the synthesis of β-difluoromethyl alcohols from cheap and widely available starting materials. In this review, we provide an overview of the latest developments in this rapidly evolving field, aiming to stimulate further research and innovation.

Graphical Abstract

Recent advances in direct 1,2-hydroxydifluoromethylation of olefins

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Volume 8, Issue 6 - Serial Number 6
November and December 2025
Pages 1269-1277

  • Receive Date 26 September 2025
  • Revise Date 27 October 2025
  • Accept Date 27 October 2025