Chemical Review and Letters

Synthesis, identification, and molecular docking of some new derivatives of ciprofloxacin drug with studying lt's biological activity and anticancer evaluation

Document Type : Research Article

Authors

Rawaa A. Ahmed
Maha Salih Hussein

Department of Chemistry, College of Education, University of Samarra, Samarra, Iraq.

https://doi.org/10.22034/crl.2025.495366.1501
Abstract
The antibacterial action of novel diazine compounds against COX-2 was predicted, and their anticancer potential was anticipated. FTIR spectroscopy, 1HNMR, 13CNMR, physical properties, and other techniques were employed to identify and describe the chemicals that were generated. Ciprofloxacin methyl ester molecule [1] was created by reacting ciprofloxacin with methanol while using intense H2SO4. By reacting ciprofloxacin methyl ester with hydrazine hydrate, compound [2] was produced. With glacial acetic acid acting as a catalyst and a solvent, hydrazide derivative [2] reacted with maleic anhydride, succinic anhydride, phthalic anhydride, and 3-nitrophthalic anhydride, respectively, to create diazine compounds [3-6]. The compounds were tested against antibacteria, specifically Staphylococcus aureus (G+) and E.Coli, and their cytotoxic efficacy against two human cancer cell lines (A549 and MCF-7) was assessed. The synthesized compounds were subjected to molecular docking tests.

Graphical Abstract

Synthesis, identification, and molecular docking of some new derivatives of ciprofloxacin drug with studying lts biological activity and anticancer evaluation

Keywords

anticancer
biological activities
ciprofloxacin
molecular docking

Subjects

Chemical Review and Letters
Volume 8, Issue 6 - Serial Number 6
November and December 2025
Pages 1228-1239

XML
PDF 2.22 M
Supplementary File
1501-Supp.pdf

  • Receive Date 22 December 2024
  • Revise Date 07 March 2025
  • Accept Date 09 March 2025

Home

Guide for Authors

Submit Manuscript

Reviewers

Contact Us