Synthesis and study of Pd (II), Pt (IV) and Au (III) complexes with amoxicillin and imidazole derivatives heterocycles as biological activity compounds

Hameed Abdulameer, Jihan; HAMZAH DAYLEE, SHAYMAA; A. Alattar, Rawaa; K. Abbas, Sawsan

doi:10.22034/crl.2024.486431.1464

Synthesis and study of Pd (II), Pt (IV) and Au (III) complexes with amoxicillin and imidazole derivatives heterocycles as biological activity compounds

Document Type : Research Article

Authors

Jihan Hameed Abdulameer ¹

SHAYMAA HAMZAH DAYLEE ¹

Rawaa A. Alattar ²

Sawsan K. Abbas ²

¹ Department of Chemistry College of Education for Pure Sciences, University of Kerbala, Iraq.

² Department of Chemistry, College of Science, University of Kerbala, Kerbala, Iraq

https://doi.org/10.22034/crl.2024.486431.1464

Abstract

In the work, a new mixed metal chloride complexes of palladium (II), platinum (IV) and gold (III) were prepared by the metal condensation reaction with amoxicillin as a primary ligand (L) with 2-(4,5-di(4-methoxyphenyl)-2-(4-(methylthio)phenyl)-1H-imidazole-1-yl)-5-methylphenoln as secondary ligand (L/).The compounds' structural were characterized by the application of analytical and spectroscopic methodologies. The results of the research showed that the coordination sites of the ligands with the metal ions were diastereomers due to amoxicillin's (L) two oxygen atoms, and in contrast, derivative imidazole(L/) using sulfur and oxygen atoms. The Pt (IV) complex was shown to have an octahedral structure through spectroscopic and analytical studies, whereas the Pd(II) and Au(III) complexes exhibited square planar structures. The ligands and the new compounds were evaluated against strains of bacteria and fungi (E.coli as Gram(-), Staphy. as Gram(+), and Cand.) at three different concentrations (50, 100, and 200) ppm. The results showed that the Au (III) complex was more effective than other compounds. Furthermore, based on the outcomes of the cytotoxic assay, the newly formed complexes were efficiently screened to examine their toxicity as an anticancer drug against MDA cell lines. Specially at high concentrations, these synthetic compounds offer potential as novel candidates for anticancer drugs in the future.

Graphical Abstract