Chemical Review and Letters

Oxybromination of styrene derivatives: Direct Access to phenacyl bromides

Document Type : Review Article

Authors

Sanoeva Matlyuba 1
Sarvinoz Khojiyeva 2
Shomirzayev Khurshidbek 3
Khakimova Zilolakhon 4
Nilufar Niyazova 5
Urinova Xulkar 6
Аbdiev Kattabek 7
Nilufar Esanmuradova 8, 9, 10
Pardaev Olim 11, 12
Tojiboev Jakhongir 13

1 DSc, Associate professor of Department of Neurology, vice rektor of Bukhara State Medical Institute, Bukhara, Uzbekistan.

2 Department of Chemistry teaching methodology, Jizzakh state pedagogical university, Jizzakh, Uzbekistan

3 Assistant of the Department of facial-jaw surgery, Andijan State Medical Institute, Uzbekistan

4 PhD, Associate Professor, Head of the Department of Propaedeutic Dentistry, Andijan State Medical Institute, Uzbekistan.

5 Department of Psychology and Medicine. Mamun university, Khiva, Uzbekistan

6 PhD, Navoi State University of Mining and Technology, Navoi, 210100, Uzbekistan

7 PhD Associate Professor, Department of Hematology, Samarkand State Medical Institute, Samarkand, Uzbekistan

8 Tashkent Institute of Irrigation and Agricultural Mechanization Engineers” National Research University, Tashkent, Uzbekistan

9 School of Engineering, Central Asian University, Tashkent 111221, Uzbekistan

10 Western Caspian University, Scientific researcher, Baku, Azerbaijan

11 1. Doctor of Economic sciences, Professor, Samarkand Institute of Economics and Service, Samarkand, Uzbekistan

12 Baku Eurasian University, Baku, AZ 1073, Azerbaijan

13 Pediatric nephrologist, Department of Nephrology, National Children’s Medical Centre, Tashkent, Uzbekistan

https://doi.org/10.22034/crl.2025.531327.1639
Abstract
Phenacyl bromides have long served as important building blocks in chemical synthesis, particularly in the preparation of heterocyclic compounds owing to their two contiguous electrophilic centers. Consequently, tremendous efforts have been devoted to the development of efficient synthetic methodologies to this specific class of carbonyl compounds. The direct vicinal oxybromination of widely available styrene derivatives is one of the most efficient procedure for preparation of the titled compounds, benefiting high step, atom and pot economy. In this Mini-Review we discuss some of the most representative and interesting recent reports on the synthesis of phenacyl bromides through the direct oxybromination of respective styrenes with an emphasis on the reaction mechanisms.

Graphical Abstract

Oxybromination of styrene derivatives: Direct Access to phenacyl bromides

Keywords

Difunctionalization
oxybromination
phenacyl bromides
styrenes
olefinic double bonds

Subjects

Chemical Review and Letters
Volume 8, Issue 4 - Serial Number 4
July and August 2025
Pages 709-719

  • Receive Date 25 June 2025
  • Revise Date 18 July 2025
  • Accept Date 17 July 2025

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