Chemical Review and Letters

Advances in transition-metal catalyzed vicinal (hydr)oxy-chlorination of styrene derivatives

Document Type : Review Article

Authors

Fardin Rezazadeh 1
Huseyn A. Imanov 2
Yunusov Obidjon Kodirovich 3
Xaldarov Nortoji 4
Uktam Ne'matov 5

1 Department of Chemistry, Faculty of Science, Urmia University, Urmia, Iran

2 Nakhchivan State University, Faculty of Natural Sciences and Agriculture, Department of Chemistry, Republic of Azerbaijan, Nakhchivan Autonomous Republic, Nakhchivan city, AZ7000

3 Tashkent State Technical University, Department of Ecology and Environmental Protection

4 Department of Natural Sciences, Samarkand State Architecture and Construction University, Samarkand, Uzbekistan

5 Assistant Professor, Department of Otorhinolaryngology, Samarkand State Medikal University, Samarkand, Uzbekistan

https://doi.org/10.22034/crl.2025.521575.1589
Abstract
The direct (hydr)oxy-chlorination reactions have emerged as a powerful tool to achieve phenacyl chlorides and 2-chloro-1-phenylethanols from easily accessible styrene derivative within a single click under benign conditions. Recent most instructive and reliable literature reports which deal with transition-metal catalyzed vicinal (hydr)oxy-chlorination of styrene derivatives, along with the precise mechanistic pathways are concisely reviewed.

Graphical Abstract

Advances in transition-metal catalyzed vicinal (hydr)oxy-chlorination of styrene derivatives

Keywords

Difunctionalization
oxy-chlorination
hydroxy-chlorination
phenacyl chlorides
styrene chlorohydrins

Subjects

Chemical Review and Letters
Volume 8, Issue 3 - Serial Number 3
Spring 2025
Pages 564-575

  • Receive Date 05 May 2025
  • Revise Date 07 June 2025
  • Accept Date 09 June 2025

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