Chemical Review and Letters

Recent advances in the construction of β-hydroxy phosphorus compounds via direct vicinal hydroxy-phosphorylation of alkenes

Document Type : Research Article

Authors

Akram Hosseinian 1
Mehriban Hamid Maharramova 2
Gunash Mazahir Nasrullayeva 2
Mehriban Rauf Yusifova 2
Rahul Raj Chaudhary 3

1 Department of Engineering Science, College of Engineering, University of Tehran, Tehran, I.R. IRAN

2 Department of Engineering and Applied Sciences of Azerbaijan State University of Economics (UNEC), 194 M.Mukhtarov str., Baku AZ1065 Azerbaijan

3 Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India

https://doi.org/10.22034/crl.2025.501726.1528
Abstract
β-Hydroxy phosphorus compounds are often encountered in numerous pharmaceuticals and bioactive molecules, and also of great importance as intermediates or building blocks in organic synthesis. Among various synthetic strategies developed, direct vicinal hydroxy-phosphorylation of easily accessible alkenes proves to be one of the most powerful and straightforward protocols to construct such privileged structures. In this review, we summarize the recent advances in the synthesis of titled compounds through the direct hydroxy-phosphorylation of alkene substrates using P(O)–H compounds, and underline the remaining challenges. This information would provide important and inspiring guidance for the researchers working in organophosphorus chemistry.

Graphical Abstract

Recent advances in the construction of β-hydroxy phosphorus compounds via direct vicinal hydroxy-phosphorylation of alkenes

Keywords

Vicinal difunctionalization
hydroxy-phosphorylation
organophosphorus compounds
β-hydroxy phosphorus compounds
P(O)–H compounds
alkenes

Subjects

Chemical Review and Letters
Volume 8, Issue 2 - Serial Number 2
Winter 2025
Pages 378-387

  • Receive Date 23 January 2025
  • Revise Date 06 April 2025
  • Accept Date 07 April 2025

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