Chemical Review and Letters

Direct C-H difluoromethyl(thiol/selenol)ation of terminal alkynes: A review

Document Type : Review Article

Authors

Khadijeh Didehban 1
Aytan A. Niyazova 2
Garay S. Mirzoev 2
Ilhama F. Allahverdiyeva 2

1 Payame Noor University, Tehran, Iran

2 Department of Engineering and Applied Sciences, Azerbaijan State University of Economics (UNEC), Baku, Azerbaijan

https://doi.org/10.22034/crl.2024.492011.1486
Abstract
The aim of the present review is to summarize the recent advances in the direct C-H difluoromethyl(chalcogen)ation of terminal alkynes. Hopefully, it can provide practical guidance for the readers who are interested in fluoroalkylation reactions. For simplicity and clarity, the review is divided into three sections: (i) difluoromethylation reactions; (ii) difluoromethylthiolation reactions; and (iii) difluoromethylselenolation reactions.

Graphical Abstract

Direct C-H difluoromethyl(thiol/selenol)ation of terminal alkynes: A review

Keywords

C-H functionalization
difluoromethylation
difluoromethylthiolation
difluoromethylselenolation
alkynes

Subjects

  • Receive Date 03 December 2024
  • Revise Date 08 January 2025
  • Accept Date 23 December 2024

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