Chemical Review and Letters

Synthsis, characterization and spectral estimation of Nickel(II), Copper (II) and their Complexes Activity as Antibacterial

Document Type : Research Article

Authors

Muhammed Naji Tawfeeq 1
Sattar Majeed 2
Eman Al Samarrai 3

1 Iraqi Ministry of Education

2 Department of Chemistry, College of Science, Univ. Of Anbar, Ramadi, Anbar, Iraq

3 Department of Chemistry, College of Education, Univ. Of Samarra, Iraq

https://doi.org/10.22034/crl.2024.474953.1411
Abstract
The study includes the synthesis and characterization of new azo compound 4-((2-amino-5-nitrophenyl)diazenyl)benzenesulfonic acid as reagent and their complexes with the two metals nickel (II) and copper (II). The complexes were prepared by mixing the azo ligand as a primary ligand and sodium pyrophosphate and malonic acid as secondary ligands using metal-ligand in a 1:1:1 mole ratio. Reagent and complexes were characterized by spectroscopic methods FTIR, UV-Visible, Atomic absorption, C.H.N and GC-Mass. The in-vitro biological activity of the ligand and the metal complexes were screened against the Gram-negative and Gram-positive pathogenic bacteria Serratia marcens and Pseudomonas aeruginosa.The copper complexes showed ahigh efficiency of antimicrobial activity compared with the ligand. Spectroscopic methods were developed to estimate nickel and copper, the best conditions was study which gave high sensitivity. It showed Linear range at 1-10 ppm with a correlation coefficient of (0.9901-0.9924). The detection limit was between (0.0715-0.0895) and the quantitative limit was between (0.2166-0.2713) ppm, the Sandel sensitivity was between (0.0166-0.0208) μg/cm2 and the Recovery% was (100.6177-101.4508).

Graphical Abstract

Synthsis, characterization and spectral estimation of Nickel(II), Copper (II) and their Complexes Activity as Antibacterial

Keywords

Azo ligand
Nickel(II) Complexes
Copper(II) Complexes
Spectroscopic methods

Subjects

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Chemical Review and Letters
Volume 7, Issue 6 - Serial Number 6
November and December 2024
Pages 1031-1041

  • Receive Date 24 August 2024
  • Revise Date 03 November 2024
  • Accept Date 06 November 2024

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