Chemical Review and Letters

Green synthesis of new spiropyrroloisatin and spiroindenopyrroles using biosynthesized CuO/ZnO@MWCNTs nanocatalyst

Document Type : Research Article

Authors

Zinatossadat Hossaini 1
Sajjad Ahmadi 2
Daryoush Zareyee 3
Somayeh Soleimani Amiri 4

1 Qaemshahr, Iran

2 Department of Chemistry, Islamic Azad University, Qaemshahr Branch, Qaemshahr, Iran

3 Islamic Azad University, Qaemshahr, Iran

4 Karaj University, Islamic Azad University

10.22034/crl.2024.472507.1400
Abstract
The synthesis of novel, high-yield derivatives of spiropyrroloisatin was investigated in this work. CuO/ZnO@MWCNTs NCs was used as a nanocatalyst in a multicomponent reaction involving isatin, ammonium acetate, ethyl 2-arylamino-4-dioxo-4-arylbutanoates, hydrazonoyl chloride in room temperature at water to create these novel compounds. Using MCRs of ninhydrin, ammonium acetate, ethyl 2-arylamino-4-dioxo-4-arylbutanoates, hydrazonoyl chloride in the presence of CuO/ZnO@MWCNTs as nanocatalysts in room-temperature water, spiropyrroloisatin were synthesized under comparable conditions. The new synthesized spirocompounds exhibits antioxidant activity since its NH group has undergone two evaluation processes. Additionally, using two types of Gram-negative bacteria in a disk distribution procedure, the antibacterial activity of recently developed spirocompounds was evaluated, and these compounds also inhibited the growth of Gram-positive bacteria. This method's benefits include quick reaction times, large product yields, and straightforward catalyst and product separation through easy steps.

Keywords

Spiropyrroloisatins
Multicomponent reaction
Isatin
Activated acetylenic compounds
CuO/ZnO@MWCNTs

Subjects

Chemical Review and Letters
Volume 7, Issue 6 - Serial Number 6
November and December 2024
Pages 1063-1073

  • Receive Date 09 August 2024
  • Revise Date 04 September 2024
  • Accept Date 06 September 2024

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