Chemical Review and Letters

Volatile profile, in silico toxicity prediction, and antioxidant and antimicrobial activities of Laurus nobilis L. essential oil from distinct geographical locations

Document Type : Research Article

Authors

Nor El Houda Tahiri 1
Najoua Soulo 2
Asmae El Ghouizi 2
Hamza Saghrouchni 3
Mostafa El Khomsi 1
Driss OUSAAID 4
Badiaa Lyoussi 2
Lalla Aicha Lrhorfi 1

1 Natural Resources and Sustainable Development Laboratory, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco;

2 Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ), University of Sidi Mohamed Ben Abdellah, Fez 30000, Morocco.

3 Department of Biotechnology, Institute of Natural and Applied Sciences, Çukurova University, 01330 Balcalı/Sarıçam, Adana, Turkey;

4 Laboratory of Natural substances, Pharmacology Environment, Modeling, Health and quality of life. Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, Fez 30000, Morocco.

https://doi.org/10.22034/crl.2024.445481.1300
Abstract
Laurus nobilis L. is one of the most interesting medicinal plants for treating different diseases. The present study was undertaken to determine the volatile profile and biological properties of Laurus nobilis L. collected from different Moroccan geographical zones. The plants investigated contained considerable amounts of antioxidants. The phytochemistry analysis showed a high variability of bioactive compounds found in both samples under study with abundance of eucalyptol (39.12%), α-terpinyl acetate (15.83%), methyleugenol (7.77%), and α-terpineol (4.74%) for sample collected from Sfrou, whereas (1R,4aR,7R,8aR)-7-(2-hydroxypropan-2-yl) (18.62%), and methyleugenol (15.84%) were the major components detected from sample originated from Akchour and did not possess hepatotoxicity, cytotoxicity, and carcinogenicity. Staphylococcus aureus was the most sensitive bacteria and registered a diameter of inhibition of 30 mm for EO from Akchour and 25 from Sefrou with a minimal inhibitory concentration (MIC) of 1/640. Both samples under study showed moderate antifungal activity against C. albicans and S. cerevisiae.

Keywords

Antibacterial effect
Antioxidant activity
Laurus nobilis
Polyphenolic compounds

Subjects

Chemical Review and Letters
Volume 7, Issue 5 - Serial Number 5
November and December 2024
Pages 884-894

  • Receive Date 24 February 2024
  • Revise Date 06 May 2024
  • Accept Date 13 June 2024

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