Physicochemical Characterization and Antimicrobial Activity of Mechanochemically and Solvent-Based Synthesized Mn(II) Complexes of Cefixime and Cefuroxime

Document Type : Research Article

Authors

1 Department of Chemistry, Faculty of Science, Federal University Gashua, Yobe State, Nigeria

2 Department of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, Maiduguri. Borno State, Nigeria

3 Department of Pure and Applied Chemistry University of Maiduguri

4 Department of Science Laboratory Technology, Mai Idiris Alooma Polytechnic, Geidam, Yobe State, Nigeria

5 Department of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, Borno State, Nigeria.

Abstract

Mechanochemical and solvent-based complexes of Mn(II) with cefixime and cefuroxime were synthesized and characterized by melting point and conductivity measurements, elemental analysis, FTIR spectral studies, and electronic spectral analysis. The Mn(II) complexes with cefixime and cefuroxime synthesized mechanochemically were both ash colored, while Mn(II) cefixime and cefuroxime complexes synthesized through solvent-based method were milky and ash respectively. The molar conductivity values (14.9 – 16.6 Scm2mol-1) indicate non-electrolytic nature of the complexes. The FTIR revealed that the ligands were coordinated to the Mn(II) ion through the carboxylate ions (C=O). A six coordinate octahedral geometry has been proposed for the complexes. The result of the antibacterial assay of the synthesized complexes of Mn(II) with cefuroxime generally showed better activity against Staphylococcus aureus, Streptococcus pyogenes and Methicillin-resistant Staphylococcus aureus (MRSA) than the free ligand cefuroxime. Similarly, the Mn(II) complex of cefuroxime synthesized by mechanochemical method shows higher activity against the aforementioned organisms as compared to the solution-based complex which might be as a result of solvent effect.

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  • Mechanochemistry: From Solid State and Soft Matter Transformation to Single Molecular Reactivity. 12-23 May. (2014). Montreal, Canada.
  • Takacs. What is Unique about Mechanochemical Reactions Department of Physics, University of Marryland, Baltimore City.126 (2014) 1040-1043.
  • A. Sayed, K. Ilka, S. Beate, B. Matthias, M. Yahya, G. Cornelia, H. Reinhard and H. Neubert. Effect of Different Metal Ions on the Biological Properties of Cefadroxil. Pharmaceuticals, 2 (2009) 1-7.
  • Parfitt, “Martindale” The Complete Drugs Reference (33rd Edition) the Pharmaceutical Press, London. (2002) P.167.
  • R. Anacona and A. Rodriguez, Syntheses and Antibacterial Activity of Ceftriaxone Metal Complexes Journal of Transition Metal Chemistry, 7 (2005) 897 – 901
  • Bergan, Pharmacokinetic Properties of the Cephalosporins Drugs. Drugs 34, Supplement 2. A Journal of Infectious Diseases, (1987) 89 -104
  • Kalman and S. L. Barriere, Review of the Pharmacokinetics and Clinical Use of Cephalosporin. Texas Heart Institute Journal, 17 (1990) 203 – 215.
  • A. Akinremi and J. A. Obaleye, Biological Activities of Some Fluoroquinolones- Metal Complexes, International Journal of Medical Biomedical Resource; 1 (2012) 24-34.
  • A. Toyin, Synthesis, Characterization and Antibacterial Activity of Cobalt(II) Complex of 8-Hydroxyquinoliine Mixed with Hydrazine. Journal for World Wide Holistic Sustainable Development.  3 (2015) 2409-9384.
  • S. Prafulla, K. Prabhjot, P. Yogini, P. Jahanvi and P. Roshani, Metalloantibiotics in Therapy. Journal of Chemical Pharmarceutical Research, 4 (2012) 4921-4936.
  • M. Khan, M. Ali and  D. Juyal, Ciprofloxacin Metal Complexes and their Biological Activities: The Pharma Innovation New Delhi. 6 (2017) 73-78.
  • C. Sharma, P.P. Giri and K. Devendra, Synthesis, Spectral and Antimicrobial Activity of Mixed ligand Complexes of Co(II), Ni(II), Cu(II) and Zn(II) with N,O and S-donor ligands, Journal of Chemical and Pharmaceutical Research. 4 (2012) 1969-1973
  • Subhasish, D. Dhanasekaran, C. Sarvanan and A. PanneerSelvan, Synthesis, Characterization and Antimicrobial Activity of Cobalt Metal Complex Against Multi Drug Resistant Bacterial and Fungal Pathogens, Physics, Chemistry and Technology; 7 (2009) 73-80.
  • Saeed, Synthesis, Characterization and Antimicrobial Studies of Transition Metal Complexes of Imidazole Derivative, Bulletin Chemical Society of Ethiopia. 24 (2010) 201-207.
  • Natarajan, K. Antonysamy, T. Chinnathangavel, Redox and Antimicrobial Studies of Transition Metal(II) Tetradentate Schiff Base Complexes. Transition Chemistry, 28 (2003) 29-36
  • G. Mohamed and N. Gamel, Synthesis, Investigatigation and Miscrocopic Characterization of Pirocan Ternary Complexes of Fe(II), Fe(III), Co(II), Ni(II) And (Zn(II) With Glycine and dl-Phenylalamine. Spectroschim Acta Part A, 60 (2004) 3141-3154.
  • Jeasmin, M. Md.Abu Hanifl, I. Saidul, H. Md Masuqul, L. Seunghee and A.B. Laila, Synthesis, Characterazation And Antimicrobial Activities of Mixed Ligand Complexes of Mn(II) With Phthalic Acid or Succinic Acid And Tetracyclic Amine. Pelagia Research Library. Der Chimica, 8 (2017) 166-174
  • A. Shelke, S.M. Jadhav, S.G. Shankarwa, A.S. Munde and T.K. Chondhekar, Synthesis, Characterization, Antimicrobial and Antifungal Studies of Some Transition and Rare Earth Metal Complexes of N-Benzyllidene-2-Hydroxy Benzony Hydrazide. Bull Chemical Society of Ethiopia. 25 (2011) 381-382
  • P. Sankaranarayana and S. L. Pushpa, Designing of Some Novel MetalloAntibiotics Tuning Biochemical Behavior Towards Therapeutics: Synthesis, Characterizationn and Pharmacological Studies of Metal Complexes of Cefixime. Journal of Saudi Chemical Society, 20 (2016) 60–66.
  • P. Ndahi, M. B. Fugu, I. Waziri and Y. A. Geidam, Effect of Mechanochemically Synthesized Copper(II) and Silver(I) Complexes with Cefuroxime on Some Cephalosporin Resistance Bacteria. International Journal of Chemistry and Pharmaceutical Sciences, 5 (2017) 155–160.

J. A. Obaleye, R. C. Mino and C. T. Adedbu, Synthesis, Characterization and Crystal Structure of a Polymeric Zinc(II) Complexes Containing the Antimalaria Quinine as Ligand. Journal of Chemical Crystallography, 37 (2007) 707-712.