Chemical Review and Letters

Investigation of some expired antibiotic drugs: Effect on the corrosion inhibition of mild steel in 0.1 M HCl medium via experimental and molecular dynamics simulation

Document Type : Research Article

Authors

Mustapha Abdullahi 1
Alhassan Kabiru Usman 1
Ahmad Muhammad Sani 2
Kamal Danazumi 2
Abdullahi Usman Umar 2
Jaafar Yusuf 2

1 Department of Pure and Applied Chemistry, Kaduna State University

2 Department of Pure and Applied Chemistry Kaduna State University

https://doi.org/10.22034/crl.2022.313874.1130
Abstract
Three expired antibiotic drugs namely, ampiclox, ciprofloxacin, and ampicillin were studied at low concentrations on the corrosion inhibition of mild steel (MS) in 0.1 M HCl medium using weight loss and scanning electron microscopy (SEM) techniques. Subsequently, the molecular structures of the antibiotic inhibitors were subjected to molecular dynamic (MD) simulation using Material Studio 8.0 software to have insight into their dynamic binding energy onto the Fe (110) surface in an acidic medium. The results showed that the weight loss and corrosion rate decrease with an increase in the inhibitor concentration, while the inhibition efficiency (%) and surface coverage increase with the increase in the inhibitor concentration respectively. The maximum inhibition efficiency of 97.72 % was attained at 0.009M concentration for ciprofloxacin followed by ampiclox and ampicillin. The SEM analysis of the MS with the expired ciprofloxacin (0.009 M) revealed a soother surface through the formation of a protective film that prevented the corrosion attack which confirms the highest inhibition efficiency. The MD simulation showed that the ciprofloxacin has the highest binding energy of -474.582 kcal/mol, followed by -248.448 kcal/mol for ampicillin and -234.955 kcal/mol for ampiclox respectively. Hence, the ciprofloxacin with the more negative magnitude of the binding energy was predicted to exhibit stronger chemisorption interaction onto the Fe (110) metal surface when compared with ampicillin and ampiclox. The findings in this research reveal good agreement between the experimental and theoretical results in studying the corrosion inhibition of the studied antibiotic drugs.

Keywords

Corrosion
Mild Steel
Molecular dynamics
Binding energy
Antibiotic drug

Subjects

  • Palit, Recent advances in corrosion science: A critical overview and a deep comprehension. Direct Synthesis of Metal Complexes, (2018)379-411. doi:10.1016/B978-0-12-811061-4.00011-6
  • K. Singh, A.K. Pandey, P. Banerjee, et al., Eco-friendly disposal of expired anti-tuberculosis drug isoniazid and its role in the protection of metal. J. Envir. Chem. Eng., 7(2) (2019) 02971. doi:10.1016/j.jece.2019.10297
  • Pal, H. Lgaz, P. Tiwari, I.M. Chung, G. Ji, R. Prakash, Experimental and theoretical investigation of aqueous and methanolic extracts of Prunus dulcis peels as green corrosion inhibitors of MS in aggressive chloride media. J. Mol. Liq., 276 (2019) 347-361. doi:10.1016/j.molliq.2018.11.099
  • Verma, E.E. Ebenso, M.A. Quraishi, Alkaloids as green and environmental benign corrosion inhibitors: An overview. Int. J. Corr. & Scale Inh., 8(3) (2019) 512-528. doi:10.17675/2305-6894-2019-8-3-3
  • Dagdag, Z. Safi, H. Erramli, et al. Anticorrosive property of heterocyclic based epoxy resins on carbon steel corrosion in acidic medium: Electrochemical, surface morphology, DFT and Monte Carlo simulation studies. J. Mol. Liq., 287 (2019) 110977. doi:10.1016/j.molliq.2019.110977
  • Abdullahi, S.E. Adeniji, D.E. Arthur, A. Haruna, Homology modeling and molecular docking simulation of some novel imidazo[1,2-a]pyridine-3-carboxamide (IPA) series as inhibitors of Mycobacterium tuberculosis. J. Gene. Eng. & Biotech., 19(1) (2021) 1-13. doi:10.1186/s43141-020-00102-1
  • Abdallah, Antibacterial drugs as corrosion inhibitors for corrosion of aluminium in hydrochloric solution. Corr. Sci., 46(8) (2004) 1981-1996. doi:10.1016/j.corsci.2003.09.031
  • C. Barenholz, Doxil®—the first FDA-approved nano-drug: lessons learned. Journal of controlled release. 160(2) (2012) 117-134.
  • Chuks, F. Anayo, O.C. Ugbogu, Health Care Waste Management – Public Health Benefits, and the Need for Effective Environmental Regulatory Surveillance in Federal Republic of Nigeria. Current Topic in Public Health, 2(2013) 149-178. doi:10.5772/53196
  • Panchal, D. Shah, R. Patel, S. Shah, M. Prajapati, M. Shah, Comprehensive Review and Critical Data Analysis on Corrosion and Emphasizing on Green Eco-friendly Corrosion Inhibitors for Oil and Gas Industries. J. Bio- and Tribo-Corrosion, 7(3) (2021) 1-29. doi:10.1007/s40735-021-00540-5
  • Dohare, D.S. Chauhan, A.A. Sorour, M.A. Quraishi, DFT and experimental studies on the inhibition potentials of expired Tramadol drug on MS corrosion in hydrochloric acid. Mat. Discov., 9(2017) 30-41. doi:10.1016/j.md.2017.11.001
  • M. Elabbasy, H.S. Gadow, Study the effect of expired tenoxicam on the inhibition of carbon steel corrosion in a solution of hydrochloric acid. J. Mol. Liq., 321(2021) 114918. doi:10.1016/j.molliq.2020.114918
  • A. Quraishi, M.Z.A. Rafiquee, S. Khan, N. Saxena. Corrosion inhibition of aluminium in acid solutions by some imidazoline derivatives. J. Appl. Electrochem., 37(10) (2007) 1153-1162. doi:10.1007/s10800-007-9379-0
  • Alfakeer, M. Abdallah, A. Fawzy, Corrosion inhibition effect of expired ampicillin and flucloxacillin drugs for MS in aqueous acidic medium. Int. J. Electrochem. Sci., 15(4) (2020) 3283-3297. doi:10.20964/2020.04.09
  • Fadila, A. Sihem, A. Sameh, K. Gülfeza. A study on the inhibition effect of expired amoxicillin on MS corrosion in 1N HCl. Mat. Research Express, 6(4) (2019) 46419. doi:10.1088/2053-1591/aafcd7

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  • Srinivasulu, P.K. Kasthuri, Study of inhibition and adsorption properties of MS corrosion by expired pharmaceutical Gentamicin drug in hydrochloric acid media. Orient. J. Chem., 33(5) (2017) 2616-2624. doi:10.13005/ojc/330559
  • Nazir, Z. Akhter, N.Z. Ali, F.U. Shah, Experimental and theoretical insights into the corrosion inhibition activity of novel Schiff bases for aluminum alloy in acidic medium. RSC Advances, 9(62) (2019) 36455-36470. doi:10.1039/c9ra07105a
  • A. Umar, A. Uzairu, G.A. Shallangwa, Understanding inhibition of steel corrosion by some potent triazole derivatives of pyrimidine through density functional theory and molecular dynamics simulation studies. J. Turk. Chem. Soc., Section A: Chemistry. 6(3) (2019) 451-462. doi:10.18596/jotcsa.446084
  • Akpan, I. A., & Offiong, N. A. O. Inhibition of mild steel corrosion in hydrochloric acid solution by Ciprofloxacin drug. J. corr., (2013).
  • M. Ayuba, M. Abubakar. A Theoretical Study on Isolated Compounds from the Leaves Extract of Guiera Senegalensis as Aluminium Corrosion Inhibitor. J. Sci. & Tech., 13(1) (2021) 47-56.

U. Umaru, A.M. Ayuba, Quantum chemical calculations and molecular dynamic simulation studies on the corrosion inhibition of aluminium metal by myricetin derivatives. J. New Tech. & Mat.,10(2020) 18-28

Chemical Review and Letters
Volume 5, Issue 4 - Serial Number 4
Summer 2022
Pages 217-225

  • Receive Date 06 November 2021
  • Revise Date 16 April 2022
  • Accept Date 03 May 2022

Home

Guide for Authors

Submit Manuscript

Reviewers

Contact Us