Propargylic ureas as powerful and versatile building blocks in the synthesis of various key medicinal heterocyclic compounds

Document Type: Review Article


1 Bowling Green State University

2 Qatar University

3 Islamic Azad University

4 Payame Noor University


This review article is an attempt to highlight the most important contributions toward the synthesis of various nitrogen-containing heterocyclic compounds from corresponding propargylic ureas through regio- and chemoselective 5-exo-dig and 6-endo-dig modes of N- and O-cyclization reactions. The review is divided into three major sections. In the first section we only focus on 5-exo-dig N-cyclization fashion. In the second section 5-exo-dig O-cyclization is described. The third section is devoted to 6-endo-dig N- and O-cyclizations

Graphical Abstract

Propargylic ureas as powerful and versatile building blocks in the synthesis of various key medicinal heterocyclic compounds


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