Colon Cancer and “BreastCancer" were considered as the almost types of solid tumor diagnosed in human It accounts for 16% of all kinds of cancer deaths globally this operation earlybiologicallybearing cyclic imides an effect components were Synthesized.The heterocyclic molecule known as Isatinbelongs toindolines, which are the most significanttypes of organic compounds. In medical chemistry, Isatin, Isatin analog and their Schiff bases have latelydrawn a greatattention. Isatin is shown to exhibitdifferentbiological activitiessuch as antiviral, antimicrobial, anti cancer, anti-inflammatory,analgesic, antioxidant as well as anticonvulsant activities. The isatinmoiety-containing BisSchiff basesare shownto own a broad spectrum of pharmacological activities.. The presentstudyprovideslatest information on the most commonly active isatinbis-Schiff bases, includingantimicrobial, anticancer, antiviral, anticonvulsant, anti-inflammatory in addition to analgesic activities.

In the current work,through an ultrasonic reaction, the complexes have been prepared so as to offer a fast, cost-effective and environmentally-friendly method.It was prepared from condensation of 2,5- diamino-phenol with Isatin in order to prepare the Schiff base compound namely [(E-2-((4-amino-2-hydroxyphenyl)imino)indol-3-one ] (3-HMIDI), followed by a reaction of the resultant compound (3-HMIDI) with Piperazin while the second ligand prepared from the condensation of 4-amino-3-hydroxybenzenesulfonamide with Isatin in order to prepare the Schiff base compound namely [Z-2-( (4-amino-2-hydroxyphenyl)-1-piperazin)1-yl methyl)indol-3-one ] (3-HDAB), followed by a reaction of the resultant compound (3-HDAB) with Piperazin.Variouscharacterization and analytical methods were usedsuch as (Mass , UV-Vis. spectroscopy in investigation of prepared ligands. Evaluation of a groupof Novel anticanceractivities of the prepared imides was done, and the results suggested that the majority of them had high anticancer activities.