Chemical Review and Letters

Efficient synthesis of 1,2,3-triazoles catalyzed by copper(I) Schiff base complex

Document Type : Research Article

Authors

Mehdi Fallah-Mehrjardi 1
Hanieh Hatami 1
Hadi Kargar 2
Khurram Shahzad Munawar 3, 4

1 Department of Chemistry, Payame Noor University (PNU), P. O. Box: 19395-4697, Tehran, Iran.

2 Department of Chemical Engineering, Faculty of Engineering, Ardakan University, P. O. Box: 184, Ardakan, Iran.

3 Department of Chemistry, University of Sargodha, Punjab, Pakistan.

4 Department of Chemistry, University of Mianwali, Mianwali, Pakistan.

https://doi.org/10.22034/crl.2025.553030.1708
Abstract
Herein, a tricoordinate Cu(I) complex was synthesized employing a neutral bidentate Schiff base (L4Cl), via the condensation of 4-chlorobenzaldehyde with 2,2-dimethylpropane-1,3-diamine, followed by complexation with copper(I) iodide. The structural features of the ligand and its corresponding complex were confirmed by FT-IR, 1H and 13C{1H} NMR spectroscopy, along with elemental (CHN) analysis. Moreover, the catalytic efficiency of the complex was evaluated in the one-pot synthesis of 1,2,3-triazoles, which are effective anticancer agents, via a three-component reaction involving phenylacetylene, sodium azide, and various benzyl bromides in aqueous medium. The optimized reaction conditions offer significant advantages, including shorter reaction times, high yields, reduced reaction temperature, and a simplified product isolation process. The efficient synthesis of triazoles using the Cu(I) complex highlights its potential as a promising catalyst for future advancements in drug development targeting malignant cells.

Graphical Abstract

Efficient synthesis of 1,2,3-triazoles catalyzed by copper(I) Schiff base complex

Keywords

1
2
3-Triazole
Aqueous medium
Copper(I) complex
Bidentate Schiff base
Homogeneous catalysis

Subjects

Chemical Review and Letters
Volume 9, Issue 1 - Serial Number 1
January and February 2026
Pages 136-143

  • Receive Date 13 October 2025
  • Revise Date 13 November 2025
  • Accept Date 28 November 2025

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