Chemical Review and Letters

Synthesis, structure, and properties of platinum(II) complexes with monoethanolamine

Document Type : Research Article

Authors

Asmat Nizami Azizova 1
Kh. I. Hasanov 1, 2
N. M. Kuliyeva 2
G. A. Mansurova 3
M. Yu. Yusifova 1
Sh. H. Qasımov 1

1 Azerbaijan Medical University, Research Center, Baku, Azerbaijan.

2 Western Caspian University, Baku, Azerbaijan.

3 AMU, Department of Pharmaceutical Toxicology and Chemistry, Baku, Azerbaijan.

https://doi.org/10.22034/crl.2025.549425.1700
Abstract
New complex compounds of platinum (II) with the biologically active ligand monoethanolamine (HL), featuring cis-, trans- [Pt(H2L)2Cl2], [Pt(H2L)2Br2] structures, as well as tetramine [Pt(H2L)4]Cl2 types, were synthesized under various conditions. Studies indicate that in all the synthesized complexes, monoethanolamine is coordinated monodentately to the nitrogen atom of the amino group, and deprotonation of the hydroxyl group of the ligand does not occur. It was determined that the composition and structure of the obtained complexes are strongly influenced by the nature of the initial platinum salts and the synthesis conditions. For instance, when cis-[Pt(NH3Cl)2] is used as the initial platinum (II) salt, its interaction with monoethanolamine under specific conditions results in the formation of a cis-complex with the composition [Pt(H2L)2Cl2]. In an alkaline medium, the reaction of PtCl2 with monoethanolamine in a 1:10 ratio produces tetramine-type complexes [Pt(H2L)4]Cl2. The structure of the resulting trans-complex [Pt(H2L)2Cl2] was confirmed through X-ray diffraction analysis. Biological testing revealed that complexes I-IV exhibit varying levels of antitumor activity.

Graphical Abstract

Synthesis, structure, and properties of platinum(II) complexes with monoethanolamine

Keywords

platinum(II)
monoethanolamine
cis-
trans-structures
hydrogen bonding
coordination
ligand
denticity
X-ray diffraction analysis

Subjects

Chemical Review and Letters
Volume 9, Issue 1 - Serial Number 1
January and February 2026
Pages 71-78

  • Receive Date 26 September 2025
  • Revise Date 25 December 2025
  • Accept Date 26 December 2025

Home

Guide for Authors

Submit Manuscript

Reviewers

Contact Us