Invitro applications of some novel Metallo-Mannich bases based on acyclovir: Antimicrobial and antioxidant activity

J. Ahmed, Tabarak; F. Alias, Mahasin

doi:10.22034/crl.2025.525296.1607

Invitro applications of some novel Metallo-Mannich bases based on acyclovir: Antimicrobial and antioxidant activity

Document Type : Research Article

Authors

Tabarak J. Ahmed

Mahasin F. Alias

Department of Chemistry, College of Science for Women, University of Baghdad. Iraq

https://doi.org/10.22034/crl.2025.525296.1607

Abstract

This study investigates the novel synthesis of Mannich base complexes, including V(IV), Ru(III), Pt(IV), and Au(III), which are produced from the Acyclovir-Mannich base. All structures of these novel compounds were described using spectroscopic approaches, including 1H,13C-NMR, UV-Vis, mass spectrometry, FTIR, metal, and elemental analysis, in addition to magnetic susceptibility and conductivity measurements. The diagnosis found that the VO-complex possesses a square pyramidal geometry, the Au-complex exhibits square planar geometry, and the Ru and Pt complexes are octahedral. All synthesized compounds were subjected to the antioxidant assay. The antioxidant activity indicates that the Ru (III) complex exhibited superior antioxidant efficacy compared to the others. The value of IC50 concerning this combination was 311.50 μg/ml. The study also involves evaluating the efficacy of these compounds in inhibiting the bacteria Acinetobacter baumannii, a Gram-negative, and Streptococcus pyogenes, a Gram-positive, as well as their antifungal activity against the microorganism Candida albicans, utilizing two separate concentrations (50 and 100) mg/ml. The data indicate that higher concentrations enhance antibacterial and antifungal action, and the Pt-complex exhibits more synergistic effectiveness and demonstrates excellent antibacterial properties against Streptococcus pyogenes.

Graphical Abstract