Recent progress in the direct sulfonylation of C(sp)-H/CO2H bonds

Document Type : Review Article

Authors

1 Department of Physics and Chemistry, Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, National Research University, Tashkent, Uzbekistan.

2 University of Tashkent for Applied Science, Tashkent, Uzbekistan.

3 Western Caspian University, Scientific researcher, Baku, Azerbaijan.

4 Literature Department of English Language and Literature, Faculty of English Language and, Andijan State Institute of Foreign Languages, Andijan, Uzbekistan.

5 Department of Mechanical Engineering Technology, Faculty of Mechanical Engineering Technology, Andijan State Technical Institute, Andijan, Uzbekistan.

6 Department of Biotechnology and Food Safety, Bukhara State University, Bukhara, Uzbekistan.

7 Department of Architecture and Computer Graphics, Faculty of Architecture and Construction, , Fergana State Technical University, Fergana, Uzbekistan.

8 Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, National Research University, Tashkent, Uzbekistan .

9 School of Engineering, Central Asian University, Tashkent, 111221, Uzbekistan.

10 Baku Eurasian University, Baku, AZ 1073, Azerbaijan.

11 Department of Fruits and Vegetable Growing, Urgench State University, Urgench, Uzbekistan.

12 Samarkand State University, Samarkand, Uzbekistan.

13 Kimyo International University in Tashkent, Samarkand, Uzbekistan.

14 Department of Nuclear Medicine and Medical Radiology, Bukhara State Medical Institute, Bukhara, Uzbekistan.

15 Scientific Research Center of Scientific Foundations and Problems of the Development of the Economy of Uzbekistan, Tashkent State University of Economics, Tashkent, Uzbekistan.

16 Department of Dentistry, Faculty of Postgraduate Education, Samarkand State Medical University, Samarkand, Uzbekistan.

10.22034/crl.2025.541787.1678
Abstract
The direct sulfonylation of terminal acetylenes and the decarboxylative sulfonylation of acetylenic acids are novel and straightforward approaches for preparing biologically and synthetically significant acetylenic sulfone derivatives. These methods offer several advantages over conventional protocols, including the utilization of inexpensive and readily accessible starting materials, improved atom and step economy, and reduced waste generation. This mini-review highlights recent advancements in these promising approaches to acetylenic sulfones, with an emphasis on the scopes, limitations and the mechanisms of the reactions.

Graphical Abstract

Recent progress in the direct sulfonylation of C(sp)-H/CO2H bonds

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Volume 8, Issue 5 - Serial Number 5
September and October 2025
Pages 1111-1121

  • Receive Date 17 August 2025
  • Revise Date 11 September 2025
  • Accept Date 13 September 2025