Chemical Review and Letters

One-pot multicomponent reactions of isatins: Green synthesis of cyclopentatriazine derivatives by employing Ag/Fe3O4/SiO2@MWCNTs MNCs as an efficient catalyst

Document Type : Research Article

Authors

A. Husein Adthab 1
Shakir Mahmood Saeed 2
Morug Salih Mahdi 3
Evan Abdulkarim Mahmood 4
Aseel Salah Mansoor 5
Usama Kadem Radi 6
Hala Bahair 7

1 Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq

2 College of Pharmacy, Alnoor University, Mosul, Iraq

3 College of MLT, Ahl Al Bayt University, Iraq

4 Medical Laboratory Science Department, College of Health Science, University of Human Development, Sulaimanyiah, Kurdistan region of Iraq

5 Gilgamesh Ahliya University, Baghdad, Iraq

6 Collage of Pharmacy, National University of Science and Technology, Dhi Qar, 64001, Iraq

7 Medical Technical College, Al-Farahidi University, Iraq

https://doi.org/10.22034/crl.2024.460102.1343
Abstract
Using a multicomponent reaction of isatin or benzaldehydes, malononitrile, ethyl 2,4-dioxo-4-arylbutanoate, ammonium acetate, and hydrazonoyl chlorides in aqueous media at room temperature in the presence of Ag/Fe3O4/SiO2@MWCNTs MNCs, this research produced cyclopentatriazines as new derivatives with a high yield. Another investigation in this work examines the antioxidant properties of the produced cyclopentatriazine. The applied method for producing cyclopentatriazine demonstrated a number of desirable traits, including quick reactions, high yields of the final product, and straightforward separation of the product and catalyst from the reaction mixture.

Graphical Abstract

One-pot multicomponent reactions of isatins: Green synthesis of cyclopentatriazine derivatives by employing Ag/Fe3O4/SiO2@MWCNTs MNCs as an efficient catalyst

Keywords

Isatin
Cyclopentatriazine
Antioxidant activity
Benzaldehyde
Multicomponent reaction
Hydrazonoyl

Subjects

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Chemical Review and Letters
Volume 7, Issue 3 - Serial Number 3
March and April 2024
Pages 441-453

  • Receive Date 01 June 2024
  • Revise Date 23 June 2024
  • Accept Date 24 June 2024

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