Recent Progress on 1,2-Hydroxyfluorination of Alkenes

Document Type : Review Article


1 College of Food Sciences, Al-Qasim Green University, Babylon, Iraq

2 Department of Pharmacy, Al-Noor University College, Nineveh, Iraq

3 College of Dentistry, National University of Science and Technology, Dhi Qar, Iraq

4 Medical Technical College, Al-Farahidi University, Iraq

5 Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq

6 Department of Chemistry, Miandoab Branch, Islamic Azad University, Miandoab, Iran



The direct fluorinative difunctionalization of alkenes is one of the most convenient platforms to the structurally complex organofluorine compounds from bulk chemicals. Accordingly, tremendous efforts to explore synthetic methodologies in this research area have been documented. In this family of reactions, the direct hydroxyfluorination of simple alkenes has emerged as a sustainable and powerful synthetic strategy for the efficient construction of vicinal fluorohydrins, which are found widespread applications in the fields of human life. The purpose of this review is to provide an overview of the available evidence on the synthesis of vicinal fluorohydrins through the direct hydroxyfluorination of corresponding alkenes. Literature has been surveyed from 1999 to the end of October 2023.


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