Direct hydroxyazidation of alkenes: A viable strategy for the synthesis of β-azido alcohols

Document Type : Review Article

Authors

1 College of Food Sciences, Al-Qasim Green University, Babylon, Iraq

2 Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq

3 Department of Pharmacy, Al-Noor University College, Nineveh, Iraq

4 National University of Science and Technology, Dhi Qar, Iraq

5 Medical Technical College, Al-Farahidi University, Iraq

6 Department of Chemistry, Payame Noor University, P.O. Box 19395-3697 Tehran, Iran

10.22034/crl.2024.430494.1270

Abstract

The aim of this review is to summarize the available literature on the direct hydroxyazidation of alkenes, with particular emphasize on the mechanistic features of the reactions. The metal-catalyzed reactions are discussed first. This is followed by iodine- and enzyme-catalyzed reactions. Finally, the available examples on light-mediated reactions will be covered at the end of this review.

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