Synthesis of New Azo Dyes of Uracil via Ecofriendly Method and Evaluation For The Breast, Liver and Lung Cancer Cells In vitro

Document Type : Research Article

Authors

1 Department of Environmental Health, College of Applied Medical Science, University of Karbala, Karbala, Iraq

2 Department of Chemistry, College of Education for Pure Science, University of Mosul, Mosul, Iraq

3 College of Food Sciences, Al-Qasim Green University, Babylon, Iraq

4 Department of Pharmacy, Al-Noor University College, Nineveh, Iraq

5 Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq

6 Pesticide Chemistry Department, National Research Centre, Dokky, Giza, Egypt.

7 Pharmaceutical Organic Chemistry Department, Faculty of pharmacy, Helwan University, Egypt.

8 Department of Chemistry, Faculty of Science and Mathematics, Sultan Idris Education University, Tanjong Malim, 35900, Perak, Malaysia

Abstract

Uracil derivatives have been the focus of many researchers examining their potential as a cancer-fighting agent. Human breast, liver, and lung cancer cells were used to test the target compounds and compared to cisplatin. There was a wide range of activity in the newly synthesized compounds against breast and lung cancer, but none were effective against liver cancer. Nevertheless, the most effective substances were 4d and 4j, which were quite effective against both kinds of cell lines. It was shown that the 4d compound is more effective against breast cancer than 4a, 4b, and 4c compounds, and 4j showed higher cytotoxic activity than 4e, 4f, and g compounds. We have been told that further research into the toxicity of these potent substances, as well as in-vivo testing, are necessary.

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Chemical Review and Letters
Volume 6, Issue 4 - Serial Number 4
December 2023
Pages 442-448

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History

  • Receive Date: 12 November 2023
  • Revise Date: 24 December 2023
  • Accept Date: 25 December 2023

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