Document Type : Review Article
Authors
1
Department of Pharmacy, Al-Noor University College, Nineveh, Iraq
2
College of Dentistry, National University of Science and Technology, Dhi Qar, Iraq
3
Medical Technical College, Al-Farahidi University, Iraq
4
Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq
5
Medical Laboratory Sciences Department, College of Health Sciences, University of Human Development, Sulaymaniyah, Iraq
6
School of Chemistry, College of Science, University of Tehran, Tehran, Iran
Abstract
1,5-benzothiazepine has proven to be one of the most attractive and useful synthetic building blocks for clinical drugs such as diltiazem, quetiapine, thiazesim, and clentiazem. Benothiazepin generally is produced from the reaction of 2-aminothiophenols on α, and β-unsaturated carbonyl compounds. Nowadays, the replacement of toxic catalysts with green reactions especially solvent-free approaches, and microwave irradiation in place of conventional heating have been developed. The new green reaction in the synthesis of 1,5- benzothiazepine The heterocycles containing this moiety widely exist in various drugs with broad spectra of biological activities, mainly central nervous system, antimicrobial, antitumor, and enzyme inhibitors.
The current minireview envisioned highlighting some recent and remarkable examples of This minireview mainly focuses on the green synthesis of 1,5-benzothiazepine diverse pharmacological properties associated with 1,5-benzothiazepine structure and covers the most relevant and recent references from 2012 to 2022.
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