Oxidative Decarboxylation of Arylacetic Acids: Novel Approach to the Synthesis of Aryl Aldehydes and Ketones

Document Type : Review Article


1 College of Dentistry, National University of Science and Technology, Dhi Qar, Iraq

2 Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq

3 Medical technical college, Al-Farahidi University, Iraq

4 Department of Pharmacy, Al-Noor University College, Nineveh, Iraq

5 Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran


Oxidation and decarboxylation are among the most important processes in organic

synthesis. The combination of these two fundamental processes provides a novel synthetic

strategy, that is, oxidative decarboxylation. Over the past few years, considerable attention

has been focused on such an attractive research arena. This review offers an overview of the

utility of oxidative decarboxylation in the synthesis of various aryl aldehydes and ketones

from the corresponding arylacetic acids. The review is divided into three major sections. The

first section focuses exclusively on metal-catalyzed reactions. The second section will discuss

metal-free approaches. The third will cover photoredox-catalyzed decarboxylative oxidations.

Literature has been surveyed from the year 1980 to 2022


Main Subjects