A novel Copper (II) Schiff base complex:synthesis,characterization,and antibacterial activity

Document Type : Research Article


Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran-Iran


The current study focuses on synthesis, characterization and antimicrobial activity of cu (II) with N-(3-nitrobenzylidene)-4-cholorobenzenamine Schiff base ligand. Coordination compound for cu (II) with N-(3n nitrobenzylidene)-4-cholorobenzenamine Schiff base ligand was derived from 3 nitro benzaldehyd an para choloro anilin Ligand and its copper complex were characterized using FT-IR, HNMR and CNMR spectra. Finally, the antimicrobial effect of the complex on E. coli was investigated by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests.FT-IR, HNMR and CNMR spectra showed the success of production new complex. Minimum inhibitory concentration and minimum bactericidal concentration studies showed the enhanced antibacterial effect of new complex on E.coli. The results showed that new complex has numerous antimicrobial effect on E.coli.


Main Subjects

  1. I. Mosa, A. A. A. Emara, J. M. Yousef, A. A. Saddiq, Acta A,2011, Novel transition metal complexes of 4-hydroxy-coumarin-3-thiocarbohydrazone: Pharmacodynamic of Co(III) on rats and antimicrobial activity. Spectrochim . Acta A., 81(1) (2011) 35-43.
  2. A. El-boraey, Spectroscopic Characterization, Antioxidant and Antitumour Studies of Novel Bromo Substituted Thiosemicabazone and Its Copper(II)، Nickel (II) and Palladium (II) Complexes, Spectrochim. Acta A., 97 (2012) 255-262.
  3. P. Dhankar, A. M. Rahatgaonkar, M. S. Chorghade, Spectral and in Vitro Antimicrobial Properties of 2-Oxo-4-Phenyl-6-Styryl-1,2,3,4- Tetrahydro-Pyrimidine-5-Carboxylic Metal Complexes, Spectrochim. Acta A., 93 (2012) 348-3.
  4. Arish, M. S. Nair Synthesis, characterization, antimicrobial, and nuclease activity studies of some metal Schiff-base complexes, J. Coord. Chem., 63 (2010) 1619-1628.
  5. Spinu, Pleniceanu, M. Isvoranu, M. Spinu, Asian J. Chem. 14 (2005) 2122.
  6. Dixit, L. Mishra, S. M. Mustafi, K. V. R. Chary, H. Houjou, Synthesis of a ruthenium(II) bipyridyl complex coordinated by a functionalized Schiff base ligand: characterization, spectroscopic and isothermal titration calorimetry measurements of M2+ binding and sensing (M2+=Ca2+, Mg2+) Spectrochim. Acta A., 73 (2009) 29-34.
  7. I. Kureshy, Balchand Dangi, Anjan Das, N. H. Khan, S. H. R. Abdi, H.C.Bajaj, Recyclable Cu(II) macrocyclic salen complexes catalyzed nitroaldol  reaction of aldehydes: A  practical  strategy in the preparation  of  phenylephrine,   Catalysis. Applied Catalysis A: General.439 (2012) 74-79.
  8. Aoyama, J. T. Kujisawa, T. Walanawe, A. Toi, H. Ogashi, Synthesis and characterization of tetra-armedthiosemicarbazone and its salen/salophen capped transition metal complexes: Investigation of their thermal and magnetic properties, J. Am. Chem. Soc., 108(5) (1986) 943-947.
  9. a: R. H. Holm, P. Kennepohl, E. I. Solomon, Iron−Sulfur Proteins with Nonredox Function, Rev., 96(7) (1996) 2239-2314. B: R. H. Holm, P. Kennepohl, E. I. Solomon, Chem. Rev. 996; 96(7) (1996) 2239-2314.
  10. Keypour, M. Shayesteh, D. Nematollahi, L. Valencia, H. A. Rudbari, J. Coord. Chem., 63(23) (2010) 4165-4176.
  11. A. El-boraey, S. M. Emam, D. A. Tolan, A. M. Elnahas, Structural studies and anticancer activity of a novel (N6O4) macrocyclic ligand and its Cu(II) complexe, Spectrochim. Acta A., 78(1) (2011) 360-70.
  12. B. Roy, Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligand, Inorg. Chim. Acta., 362 (2009) 1709-1714.
  13. C. Pessoa, I. Cava Complexes with New N2O2 Schiff Base Ligand co, I. Correia, M. T. Duarte, R. D. Gillard, R. T. Henriques, F. J. Higes C, Madeira, I. Tomaz, Inorg. Chim. Acta., 293 (1999) 1-11.
  14. B. Badwaik, R. D. Deshmukh, A. S. Aswar, J. Coord. Chem., 62 (2009) 2037.
  15. Arish, M. S. Nair, J. Mol. Stru., 983 (2010) 112-121. N. Patel, K. K. Shukla, A. Singh, M. Choudhary, D. K. Patel, J. Niclós-Gutiérrez, D. Choquesillo-Lazarte, J. Coord. Chem., 63(20) (2010) 3648-3661.
  16. Yosif, A. Majeed, N. Salih, J. Salimon, Arabian j. Chem., 52 (2013) 2037.
  17. J. Lian, X. T. Wang, C. Z. Xie, H. Tian, X. Q. Song, H. T. Pan, ... & J. Y. Xu, Mixed-ligand copper (II) Schiff base complexes: the role of the co-ligand in DNA binding, DNA cleavage, protein binding and cytotoxicity. Dalton Transactions.45(22) (2016) 9073-9087.
  18. S. Abu-Khadra, R. S. Farag, & A. E. D. M. Abdel-Hady, Synthesis, characterization and antimicrobial activity of Schiff base (E)-N-(4-(2-hydroxybenzylideneamino) phenylsulfonyl) acetamide metal complexes. American Journal of Analytical Chemistry.7(03) (2016) 233.
  19. S. Aazam, A.F. EL Husseiny, H.M. Al-Amri, Synthesis and photoluminescent properties of a Schiff-base ligand and its mononuclear Zn(II), Cd(II), Cu(II), Ni(II) and Pd(II) metal complexes. Arabian Journal of Chemistry 5 (2012) 45–53.
  20. Jia, N. Tang, & J. J. Vittal, Zinc (II) and copper (II) 1Dcoordination polymeric complexes of a reduced Schiff base ligand. Inorganica Chimica Acta., 362(8) (2009) 2525-2528.
  21. Chandra, & A. K. Sharma, Nickel (II) and copper (II) complexes with Schiff base ligand 2, 6-diacetylpyridine bis (carbohydrazone): synthesis and IR, mass, 1H NMR, electronic and EPR spectral studies. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy., 72(4) (2009) 851-857.
  22. Gull, S. A. AL-Thabaiti, & A. A. Hashmi, Design, Characterization and antimicrobial activity of Cu (II), Co (II) and Zn (II) complexes with Schiff base from 1, 2-diphenylethane-1, 2-dione and N-(1-Naphthyl) ethylenediamine. Int. J. Multidiscip. Curr. Res.2(6) (2014) 1142-1147.
  23. O. Sobola, G. M. Watkins, & B. Van Brecht, Synthesis, characterization and antimicrobial activity of copper (II) complexes of some ortho-substituted aniline Schiff bases; crystal structure of bis (2-methoxy-6-imino) methylphenol copper (II) complex. South African Journal of Chemistry., 67 (2014) 45-51.