Green and Highly Efficient Synthetic Approach for the Synthesis of 4-Aminoantipyrine Schiff Bases

Document Type : Research Article


Department of Chemistry, College of Science, Salahaddin University, Erbil, Kurdistan Region - Iraq.


The analog of 4-aminoantipyrine (4-amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazole-3-one), is interesting in the field of pharmacology and pharmaceutical chemistry and plays an important role as the ingredients for the production of the drugs and medicines. In the current study, a series of Schiff (including two new compounds) bases have been synthesized from 4-aminoantipyrine and substituted benzaldehydes via a simple and easy procedure in a short time with high yields. The structures of products have been characterized by (FTIR, 1HNMR, 13CNMR, and Elemental Analysis).


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