A novel [3-(4-methoxyphenyl)isoxazole-5-yl]-methanol compound: synthesis and effect on corrosion inhibition of copper in 1 M sulfuric acid solution

Document Type : Research Article


1 Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran

2 Department of Chemistry, Faculty of Science, University of Mohaghegh Ardabili, P.O. Box 179, Ardabil, Iran


[3-(4-Methoxyphenyl)isoxazole-5-yl]-methanol was synthesized and used as an efficient inhibitor to protect copper in 1 M sulfuric acid solution. Corrosion studies were performed by electrochemical techniques, including electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP), and quantum chemical calculations (Gaussian). The effect of temperature on the copper corrosion and inhibitor performance was also investigated. The data obtained from the analysis of the polarization curves disclosed that the corrosion current density (Icorr) of the metal dissolution decreased in the presence of inhibitor. This may indicate a reduction in the corrosion rate, resulting from the adsorption of inhibitor molecules on the active sites of the copper surface. Such a result was confirmed by the measured Nyquist diagrams, where total resistance increased with the addition of inhibitor to the medium. Langmuir’s adsorption isotherm was confined as best fitted isotherm describes the physical-chemical adsorption capability of the inhibitor on the copper surface. The results revealed that [3-(4-Methoxyphenyl)isoxazole-5-yl]-methanol could effectively improve the corrosion resistance of copper. The theoretical calculation of quantum chemical demonstrated the experimental findings.


Main Subjects

  • Gong, S. Peng, X. Huang, L. Gao, Investigation the corrosion inhibition effect of itraconazole on copper in H2SO4 at different temperatures: Combining experimental and theoretical studies, Materials (Basel). 11 (2018) 2107.
  • Jmiai, B. El Ibrahimi, A. Tara, M. Chadili, S. El Issami, O. Jbara, A. Khallaayoun, L. Bazzi, Application of Zizyphus Lotuse-pulp of Jujube extract as green and promising corrosion inhibitor for copper in acidic medium, J. Mol. Liq. 268 (2018) 102–113.
  • Zhang, L. Zhang, G. Tao, A novel and high-efficiency inhibitor of 5-(4-methoxyphenyl)-3h-1, 2-dithiole-3-thione for copper corrosion inhibition in sulfuric acid at different temperatures, J. Mol. Liq. 272 (2018) 369–379.
  • Xu, S. Zhang, W. Li, L. Guo, S. Xu, L. Feng, L.H. Madkour, Experimental and theoretical investigations of some pyrazolo-pyrimidine derivatives as corrosion inhibitors on copper in sulfuric acid solution, Appl. Surf. Sci. 459 (2018) 612–620.
  • Ashassi-Sorkhabi, S. Moradi-Alavian, A. Kazempour, Salt-nanoparticle systems incorporated into sol-gel coatings for corrosion protection of AZ91 magnesium alloy, Prog. Org. Coatings. 135 (2019) 475–482.
  • Ashassi-Sorkhabi, A. Kazempour, Chitosan, its derivatives and composites with superior potentials for the corrosion protection of steel alloys: A comprehensive review, Carbohydr. Polym. (2020) 116110.
  • Ashassi-Sorkhabi, A. Kazempour, Incorporation of organic/inorganic materials into polypyrrole matrix to reinforce its anticorrosive properties for the protection of steel alloys: A review, J. Mol. Liq. (2020) 113085.
  • Ashassi-Sorkhabi, S. Moradi-Alavian, R. Jafari, A. Kaz

empour, E. Asghari, Effect of amino acids and montmorillonite nanoparticles on improving the corrosion protection characteristics of hybrid sol-gel coating applied on AZ91 Mg alloy, Mater. Chem. Phys. 225 (2019) 298–308.

  • Ashassi-Sorkhabi, S. Moradi-Alavian, M.D. Esrafili, A. Kazempour, Hybrid sol-gel coatings based on silanes-amino acids for corrosion protection of AZ91 magnesium alloy: Electrochemical and DFT insights, Prog. Org. Coatings. 131 (2019) 191–202.
  • Zhou, S. Zhang, B. Tan, L. Feng, B. Xiang, F. Chen, W. Li, B. Xiong, T. Song, Phenothiazine drugs as novel and eco-friendly corrosion inhibitors for copper in sulfuric acid solution, J. Taiwan Inst. Chem. Eng. 113 (2020) 253–263.
  • Palaniappan, J. Alphonsa, I.S. Cole, K. Balasubramanian, I.G. Bosco, Rapid investigation expiry drug green corrosion inhibitor on mild steel in NaCl medium, Mater. Sci. Eng. B. 249 (2019) 114423.
  • Abdallah, E.A.M. Gad, M. Sobhi, J.H. Al-Fahemi, M.M. Alfakeer, Performance of tramadol drug as a safe inhibitor for aluminum corrosion in 1.0 M HCl solution and understanding mechanism of inhibition using DFT, Egypt. J. Pet. 28 (2019) 173–181.
  • C. Anadebe, O.D. Onukwuli, F.E. Abeng, N.A. Okafor, J.O. Ezeugo, C.C. Okoye, Electrochemical-kinetics, MD-simulation and multi-input single-output (MISO) modeling using adaptive neuro-fuzzy inference system (ANFIS) prediction for dexamethasone drug as eco-friendly corrosion inhibitor for mild steel in 2 M HCl electrolyte, J. Taiwan Inst. Chem. Eng. 115 (2020) 251–265.
  • Mohamadian-Kalhor, L. Edjlali, H. Basharnavaz, M. Es’haghi, Aluminum Fumarate Metal–Organic Framework: Synthesis, Characterization, and Application as a Novel




















































Inhibitor against Corrosion of AM60B Magnesium Alloy in Ethylene Glycol Solution, J. Mater. Eng. Perform. (2021) 1–7.

  • Sadeghzadeh, L. Ejlali, M. Eshaghi, H. Basharnavaz, K. Seyyedi, Corrosion inhibition of mild steel surface by isoxazoles in HCl solution: Electrochemical studies, Chem. Rev. Lett. 4 (2021) 2–9.
  • Ashassi-Sorkhabi, A. Kazempour, Z. Frouzat, Superior potentials of hydrazone Schiff bases for efficient corrosion protection of mild steel in 1.0 M HCl, J. Adhes. Sci. Technol. 35 (2021) 164–184.