Synthesis of Novel Michael Adducts and Study of their Antioxidant and Antimicrobial Activities

Document Type : Research Article

Authors

1 Department of Chemistry, College of Science, Salahaddin University - Erbil, Kurdistan Region - Iraq

2 Department of Chemistry, College of Science, Salahaddin University-Erbil, Kurdistan Region - Iraq

Abstract

In the current study, the Michael addition reaction of nitromethane to chalcones were studied. 4-benzeloxy benzaldehyde was synthesized from 4-hydroxybenzaldehde and benzyl bromide, which was then converted to chalcone derivatives by reaction with substituted acetophenones, and finally nitromethane was added to give Michael adducts. The structures of the synthesized compounds were characterized by FTIT, 1H NMR, and 13C NMR spectroscopy. All the products were screened for antibacterial activities against Staphylococcus aureus G (+ve) and Escherichia coli G (-ve) microorganisms and antifungal activity against candida albicans besides their antioxidant activity.

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Volume 5, Issue 4 - Serial Number 4
August 2022
Pages 226-233
  • Receive Date: 04 July 2022
  • Revise Date: 12 July 2022
  • Accept Date: 18 July 2022
  • First Publish Date: 18 July 2022