Synthesis and crystallization procedure of piperidin-4-one and its derivatives: An update

Document Type : Review Article

Author

Department of Electrical and Computer Engineering, National University of Singapore, 117 583, Singapore

10.22034/crl.2021.278234.1105

Abstract

Piperidine is a heterocyclic chemical molecule that is forming by hydrogenating pyridine. In natural and pharmaceutically active drugs, the piperidine ring is an essential molecular component. Several crystal structures of piperidine-4-ones and their derivatives are reported for their medicinal value. While several methods of piperidin-4-one crystallization have been developed to obtain a crystal structure, novel approaches are still needed. A review of the synthesis and crystallization procedure of piperidin-4-ones and its derivatives is outlined in this review paper.

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