Synthesis and crystallization procedure of piperidin-4-one and its derivatives: An update

Document Type : Review Article


Department of Electrical and Computer Engineering, National University of Singapore, 117 583, Singapore


Piperidine is a heterocyclic chemical molecule that is forming by hydrogenating pyridine. In natural and pharmaceutically active drugs, the piperidine ring is an essential molecular component. Several crystal structures of piperidine-4-ones and their derivatives are reported for their medicinal value. While several methods of piperidin-4-one crystallization have been developed to obtain a crystal structure, novel approaches are still needed. A review of the synthesis and crystallization procedure of piperidin-4-ones and its derivatives is outlined in this review paper.


Main Subjects

Volume 4, Issue 4 - Serial Number 4
August 2021
Pages 192-199
  • Receive Date: 23 March 2021
  • Revise Date: 04 June 2021
  • Accept Date: 17 June 2021
  • First Publish Date: 17 June 2021