Efficient and environmentally sustainable domino protocol for the synthesis of diversified dispiroheterocycles using 1-Butyl-3-methylimidazolium bromide [bmim]Br

Document Type : Research Article

Authors

1 Department Of Chemistry, Dr.Babasaheb Ambedkar Marathawada University, Aurangabad

2 Department of Chemistry, Dr.Babasaheb Ambedkar Marathwada University, Aurangabad

3 Department of Chemistry, Dr.Babasaheb Ambedkar Marathawada University, Aurangabad

4 Department of Chemistry, Shivaji Art, Commerce and Science College, Kannad, Aurangabad 431103, Maharashtra, India

Abstract

An environmentally benign, simple, and efficient procedure has been developed for the construct of some symmetrical dispiroheterocycles derivatives by the reaction of the variety of 6-amino-2-thiouracil/6-aminouracil /2-amino-1,3,4-thiadiazole, isatins and p-toluidine in the presence of 1-Butyl-3-methylimidazolium bromide ([bmim]Br) as a solvent as well as catalyst at room temperature. In this study, a variety of bis-spiro-indoline-chromenes, pyranopyranes, imidazo-pyridines, pyrido-pyrimidines and pyridines were obtained with excellent yields within short reaction time and without chromatographic separation. Furthermore, the green catalytic system can be recycled specific times with no decreases in yields and reaction rates.

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History

  • Receive Date: 30 March 2021
  • Revise Date: 05 June 2021
  • Accept Date: 14 June 2021
  • First Publish Date: 14 June 2021

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