@article { author = {Ramalingam, Arulraj}, title = {Synthesis and crystallization procedure of piperidin-4-one and its derivatives: An update}, journal = {Chemical Review and Letters}, volume = {4}, number = {4}, pages = {192-199}, year = {2021}, publisher = {Eurasian Science Society (ESS)}, issn = {2676-7279}, eissn = {2645-4947}, doi = {10.22034/crl.2021.278234.1105}, abstract = {Piperidine is a heterocyclic chemical molecule that is forming by hydrogenating pyridine. In natural and pharmaceutically active drugs, the piperidine ring is an essential molecular component. Several crystal structures of piperidine-4-ones and their derivatives are reported for their medicinal value. While several methods of piperidin-4-one crystallization have been developed to obtain a crystal structure, novel approaches are still needed. A review of the synthesis and crystallization procedure of piperidin-4-ones and its derivatives is outlined in this review paper.}, keywords = {Piperidin-4-ones,2,6-disubstituted piperidin-4-ones,Recrystallization,Chair conformation,Boat conformation}, url = {https://www.chemrevlett.com/article_132113.html}, eprint = {https://www.chemrevlett.com/article_132113_57451e45b884209613a9d1d8167163e9.pdf} }